How the best American companies Innovate ? What is the Management structure of Clusters in Massachusetts? How innovative companies access the venture capital firms? What is the ecosystem of Boston that makes it has a high rate of success in their ventures ? All these aspects were studied with leadnig professors of international recognition , Jay Rao of Babson College, Leon Sandler of the Deshpande Center at MIT, and Eric Paley of Founder Collective. The course was managed by TLC, The Cluster Manager of FEMAC, Enric Pedrós participated in cooperation with a group of 10 Cluster Managers of Catalonia, and ACC10.